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Oxidative stress and protective effects of polyphenols: Comparative studies in human and rodent kidney. A review [An article from: Comparative Biochemistry and Physiology, Part C] | ![Oxidative stress and protective effects of polyphenols: Comparative studies in human and rodent kidney. A review [An article from: Comparative Biochemistry and Physiology, Part C]](http://ecx.images-amazon.com/images/I/51A51TBEEML._SL160_.jpg)
 enlarge | Authors: R. Rodrigo, C. Bosco
Publisher: Elsevier
Category: Book
Buy New: $14.95
Sales Rank: 4447186
Format: Html
Media: Digital
ASIN: B000RR6JL0
Availability: Available for download now
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Product Description
This digital document is a journal article from Comparative Biochemistry and Physiology, Part C, published by Elsevier in . The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.
Description:
Reactive oxygen species (ROS) play a key role in the pathophysiological processes of a wide range of renal diseases. Thus, antioxidants are expected to decrease the vulnerability of the kidney to oxidative challenges. Polyphenols, particularly abundant in red wine, could act as ROS scavengers, iron chelators and enzyme modulators. In addition, chronic exposure to moderate amounts of ethanol results in increased activity of the renal antioxidant enzymes, further supporting a renoprotective effect of red wine based on its antioxidant properties. An enhancement of plasma antioxidant capacity following red wine consumption has been reported both in man and rodents, thereby providing a contributory factor to its renoprotective effect because the kidney is a highly perfused organ. Although phenol concentration of red wine does not influence the activity of antioxidant enzymes of the kidney, the concentration of these compounds is negatively correlated with tissue lipid peroxidation, assessed by thiobarbituric acid reactive substances, and positively correlated with the antioxidant capacity of plasma. Moreover, amelioration of myoglobinuric renal damage was found in rats following chronic exposure to flavonol-rich red wine. Also, pretreatment with resveratrol, or other red wine polyphenols, decreased kidney damage caused by ischaemia-reperfusion. The aim of the present review is to examine the pathophysiological basis of the renoprotective effect of red wine in man and rodents, based on functional, biochemical and ultrastructural evidence.
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